LMNB2

Across TCGA patient cohorts, LMNB2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMNB2-associated genes across cancer lineages are FOXO3a_pS318_S321, PDCD4, and Rab11. Each is linked with LMNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMNB2-to-partner and partner-to-LMNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by LMNB2-low versus LMNB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNB2→partner) and Y-score (partner→LMNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.145	-3.169	.012	.018	3	1
UCEC	PDCD4 →	-0.593	-2.584	.006	.011	3	1
UCEC	Rab11 →	-0.163	-2.584	.015	.011	3	1
UCEC	Rad50 →	-0.281	-3.000	.013	.036	3	1
UCEC	ASNS →	+0.546	+2.999	.001	.035	3	1
UCEC	C-Raf →	+0.251	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a_pS318_S321 by LMNB2 expression — UCEC

Explore this box plot interactively →