LMNB2

Across TCGA pan-cancer cohorts, LMNB2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LMNB2 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher LMNB2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LMNB2 expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

MESO, ACC, and KIRC are the cancer types where LMNB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.364	0.714	<.001	159	view →
ACC	DFS	Median	All	0.230	0.662	<.001	154	view →
KIRC	DFS	Quartile	II,III,IV	0.453	0.733	<.001	93	view →
KIRP	DFS	Tertile	All	0.733	0.918	<.001	81	view →
LIHC	OS	Tertile	All	0.673	0.837	<.001	74	view →
LUAD	OS	Median	All	0.607	0.754	<.001	63	view →
BLCA	DFS	Quartile	All	0.410	0.589	.001	63	view →
SKCM	DFS	Median	All	0.666	0.842	<.001	58	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	58	view →
LGG	DFS	Median	All	0.312	0.494	<.001	54	view →
PAAD	DFS	Median	All	0.190	0.389	<.001	43	view →
SARC	OS	Median	All	0.427	0.590	<.001	39	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LMNB2–MESO (OS)

Open the MESO breakdown →