LMNB1

Across TCGA patient cohorts, LMNB1 mutation is significantly associated with the RNA expression of many other genes, with 1,588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMNB1-associated genes across cancer lineages are PSAT1P4, SHQ1P1, and PGBD4P2. Each is linked with LMNB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LMNB1-to-partner and partner-to-LMNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by LMNB1-low versus LMNB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNB1→partner) and Y-score (partner→LMNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSAT1P4 →	+0.326	+4.463	<.001	.002	3	3
UCEC	SHQ1P1 →	+0.015	+1.936	.003	.008	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
HNSC	TSPY7P →	+0.039	+7.954	<.001	.008	3	1
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU6-159P →	+0.274	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,588 associations by consensus.

PSAT1P4 by LMNB1 expression — COAD

Explore this box plot interactively →