LMNB1

Across TCGA patient cohorts, LMNB1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMNB1-associated genes across cancer lineages are ATM, 14-3-3_beta, and ERK2. Each is linked with LMNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMNB1-to-partner and partner-to-LMNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by LMNB1-low versus LMNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNB1→partner) and Y-score (partner→LMNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.520	-3.571	.002	.002	3	2
UCEC	14-3-3_beta →	-0.107	-2.558	.005	.010	3	1
UCEC	ERK2 →	+0.220	+2.584	.002	.001	3	1
UCEC	FOXO3a →	-0.087	-1.861	.025	.049	3	1
UCEC	Heregulin →	-0.133	-3.308	.004	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.160	-2.459	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by LMNB1 expression — UCEC

Explore this box plot interactively →