LMNA

Across TCGA cell cohorts, LMNA mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LMNA-associated genes across cancer lineages are GZMK, HPCAL4, and HHLA1. Each is linked with LMNA in more than 1 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by LMNA-low versus LMNA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GZMK →	+0.446	+3.359	<.001	.002	3	1
BLOOD_Leukemia	HPCAL4 →	+0.322	+3.825	<.001	.002	3	1
BLOOD_Leukemia	HHLA1 →	+0.007	+3.381	<.001	.002	3	1
BLOOD_Leukemia	GSC →	+1.020	+2.948	<.001	.008	3	1
BLOOD_Leukemia	STAC2 →	+0.376	+3.744	<.001	.003	3	1
BLOOD_Leukemia	OR1Q1 →	+0.340	+3.655	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GZMK by LMNA expression — BLOOD_Leukemia

Explore this box plot interactively →