LMF1

Across TCGA patient cohorts, LMF1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMF1-associated genes across cancer lineages are eIF4E, eEF2, and EGFR_pY1068. Each is linked with LMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMF1-to-partner and partner-to-LMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LMF1-low versus LMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMF1→partner) and Y-score (partner→LMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.238	+3.013	.015	.018	3	2
UCEC	eEF2 →	+0.413	+2.584	.013	.011	3	1
UCEC	EGFR_pY1068 →	-0.285	-3.321	.014	.010	3	1
UCEC	A-Raf_pS299 →	-0.187	-3.000	<.001	.036	3	1
UCEC	ERK2 →	+0.289	+3.459	.001	.005	3	1
UCEC	INPP4B →	-0.314	-2.999	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by LMF1 expression — UCEC

Explore this box plot interactively →