LMF1

Across TCGA cell cohorts, LMF1 mutation is significantly associated with the mutation status of many other genes, with 2,900 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMF1-associated genes across cancer lineages are MAP3K1, TRAF3IP1, and EEF2K. Each is linked with LMF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LMF1-to-partner and partner-to-LMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP3K1 grouped by LMF1-low versus LMF1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMF1→partner) and Y-score (partner→LMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP3K1 →	+3.095	+3.558	.008	.008	1	4
LUNG_SCLC	TRAF3IP1 →	+4.502	+5.066	.007	.007	1	4
BREAST	EEF2K →	+4.095	+4.095	.002	.002	1	3
BREAST	TMEM175 →	+3.925	+4.974	<.001	<.001	1	3
BREAST	TAF4 →	+3.510	+3.807	.004	.004	1	3
BREAST	ACE →	+3.510	+3.807	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,900 associations by consensus.

MAP3K1 by LMF1 expression — BREAST

Explore this box plot interactively →