LMBR1

Across TCGA cell cohorts, LMBR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,088 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LMBR1-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Regulation of nucleotide-excision repair, and Positive regulation of DNA repair. Each is linked with LMBR1 in more than 15 cancer types. Because this analysis shows association rather than direction, both LMBR1-to-partner and partner-to-LMBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by LMBR1-low versus LMBR1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LMBR1→partner) and Y-score (partner→LMBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.201	+1.398	.001	<.001	3	16
SOFT_TISSUE	Regulation of nucleotide-excision repair →	+0.094	+0.887	<.001	<.001	3	12
SOFT_TISSUE	Positive regulation of DNA repair →	+0.059	+0.853	<.001	<.001	3	11
PANCREAS	Regulation of isotype switching to IgG isotypes →	+0.121	+0.847	<.001	.001	3	11
SOFT_TISSUE	Regulation of DNA repair →	+0.055	+0.713	.001	.002	3	11
SOFT_TISSUE	Regulation of G0 to G1 transition →	+0.088	+0.971	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,088 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by LMBR1 expression — LUNG_NSCLC_LUSC

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