LMBR1

Across TCGA pan-cancer cohorts, LMBR1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LMBR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LMBR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LMBR1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, KIRP, and COAD are the cancer types where LMBR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LMBR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.932	<.001	12	view →
KIRP	Female	II,III,IV	+1.105	<.001	11	view →
COAD	Male	All	+1.114	<.001	10	view →
LUAD	Male	III,IV	+1.055	<.001	9	view →
LIHC	Male	All	+0.643	<.001	9	view →
BLCA	All	III,IV	+0.568	<.001	9	view →
BRCA	All	III,IV	+0.597	<.001	6	view →
CHOL	Male	All	+1.531	<.001	5	view →
LUSC	All	All	+0.484	<.001	5	view →
READ	All	All	+0.702	.007	4	view →
STAD	All	II,III,IV	+0.614	.001	4	view →
THCA	Male	II,III,IV	−0.391	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LMBR1–HNSC

Open the HNSC breakdown →