LLPH-DT

Across TCGA pan-cancer cohorts, LLPH-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LLPH-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LLPH-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LLPH-DT expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

ACC, MESO, and UCS are the cancer types where LLPH-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.171	0.612	<.001	72	view →
MESO	DFS	Quartile	All	0.540	0.276	.010	45	view →
UCS	DFS	Quartile	III,IV	0.542	0.145	.007	30	view →
BLCA	DFS	Quartile	All	0.549	0.697	.015	24	view →
HNSC	DFS	Quartile	IV	0.763	0.542	.002	23	view →
BRCA	DFS	Tertile	II,III,IV	0.860	0.919	.007	22	view →
STAD	DFS	Median	II,III,IV	0.676	0.546	.027	22	view →
LIHC	DFS	Quartile	All	0.187	0.367	.011	19	view →
THCA	DFS	Median	All	0.917	0.967	.010	17	view →
LGG	DFS	Quartile	All	0.823	0.705	.007	16	view →
THYM	DFS	Quartile	All	1.000	0.814	.010	16	view →
LUAD	OS	Quartile	III,IV	0.760	0.469	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LLPH-DT–ACC (DFS)

Open the ACC breakdown →