LLPH-DT

Across TCGA pan-cancer cohorts, LLPH-DT RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LLPH-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LLPH-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LLPH-DT is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where LLPH-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LLPH-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.631	<.001	9	view →
BLCA	All	All	+0.648	.001	6	view →
THCA	All	All	−0.508	.001	6	view →
STAD	All	II,III,IV	+0.669	.042	2	view →
LIHC	All	All	+0.306	.014	2	view →
LUSC	All	All	+0.297	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LLPH-DT–HNSC

Open the HNSC breakdown →