LLGL2

Across TCGA cell cohorts, LLGL2 mutation is significantly associated with the RNA expression of many other genes, with 541 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LLGL2-associated genes across cancer lineages are CD3G, FAM149A, and ULBP1. Each is linked with LLGL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LLGL2-to-partner and partner-to-LLGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD3G grouped by LLGL2-low versus LLGL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLGL2→partner) and Y-score (partner→LLGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CD3G →	+0.049	+2.942	.005	.004	3	2
LARGE_INTESTINE	FAM149A →	+1.337	+3.067	<.001	.009	3	2
BLOOD_Leukemia	ULBP1 →	+1.427	+3.489	<.001	.001	3	2
LARGE_INTESTINE	SNX6 →	+0.581	+3.364	.003	.002	3	2
LARGE_INTESTINE	ZNF18 →	+0.612	+3.364	<.001	.002	3	2
LARGE_INTESTINE	RAB33B →	+0.623	+3.364	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 541 associations by consensus.

CD3G by LLGL2 expression — SKIN

Explore this box plot interactively →