LLGL1

Across TCGA cell cohorts, LLGL1 mutation is significantly associated with the RNA expression of many other genes, with 420 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LLGL1-associated genes across cancer lineages are HIPK4, IZUMO1R, and SLC32A1. Each is linked with LLGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LLGL1-to-partner and partner-to-LLGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIPK4 grouped by LLGL1-low versus LLGL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LLGL1→partner) and Y-score (partner→LLGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIPK4 →	+0.050	+3.459	.002	.009	3	2
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
BLOOD_Leukemia	SLC32A1 →	+0.938	+3.223	<.001	.004	3	1
BLOOD_Leukemia	BHLHE23 →	+1.069	+3.539	.001	.005	3	1
BLOOD_Leukemia	GSC →	+0.867	+4.211	.001	<.001	3	1
BLOOD_Leukemia	NGF →	+0.333	+3.594	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

HIPK4 by LLGL1 expression — BLOOD_Leukemia

Explore this box plot interactively →