LLGL1

Across TCGA pan-cancer cohorts, LLGL1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LLGL1 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher LLGL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LLGL1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

UCS, SCLC, and MESO are the cancer types where LLGL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.787	0.154	<.001	90	view →
SCLC	OS	Median	All	0.820	0.576	<.001	82	view →
MESO	DFS	Quartile	All	0.309	0.585	.003	81	view →
LIHC	OS	Median	All	0.610	0.761	<.001	62	view →
READ	DFS	Median	All	0.896	0.549	<.001	48	view →
KIRC	DFS	Median	All	0.897	0.704	<.001	46	view →
KICH	DFS	Tertile	II,III,IV	0.453	1.000	.007	30	view →
ESCA	OS	Median	II,III,IV	0.664	0.375	<.001	28	view →
UCEC	DFS	Tertile	IV	0.837	0.524	.020	24	view →
ACC	DFS	Tertile	All	0.458	0.810	<.001	23	view →
LUSC	DFS	Median	III,IV	0.522	0.916	.007	20	view →
BRCA	OS	Median	III,IV	0.941	0.859	.002	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LLGL1–UCS (OS)

Open the UCS breakdown →