LIX1

Across TCGA patient cohorts, LIX1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIX1-associated genes across cancer lineages are Rab25, eEF2, and EGFR_pY1068. Each is linked with LIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIX1-to-partner and partner-to-LIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by LIX1-low versus LIX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIX1→partner) and Y-score (partner→LIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.324	-3.000	.036	.036	3	2
UCEC	eEF2 →	+0.456	+3.169	.006	.019	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.999	.016	.035	3	1
UCEC	ERK2 →	+0.227	+2.321	.011	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.217	-3.321	.005	.010	3	1
UCEC	MIG-6 →	+0.099	+1.887	.032	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Rab25 by LIX1 expression — UCEC

Explore this box plot interactively →