LIX1-AS1

Across TCGA pan-cancer cohorts, LIX1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated LIX1-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LIX1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIX1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

UCEC, UVM, and KICH are the cancer types where LIX1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.757	0.890	<.001	106	view →
UVM	OS	Median	All	0.343	0.720	<.001	85	view →
KICH	DFS	Median	All	0.695	0.976	.001	81	view →
LIHC	OS	Median	All	0.711	0.830	.001	74	view →
LUAD	OS	Quartile	III,IV	0.886	0.625	.003	64	view →
UCS	DFS	Median	IV	0.952	0.367	.001	60	view →
KIRP	OS	Quartile	All	0.522	0.780	<.001	45	view →
KIRC	DFS	Quartile	All	0.760	0.875	.012	36	view →
ACC	OS	Median	All	0.779	0.945	.005	34	view →
PAAD	DFS	Median	All	0.629	0.379	.002	31	view →
MESO	DFS	Median	All	0.282	0.447	.005	20	view →
LGG	OS	Tertile	All	0.335	0.530	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

LIX1-AS1–UCEC (DFS)

Open the UCEC breakdown →