LIPT1

Across TCGA cell cohorts, LIPT1 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIPT1-associated genes across cancer lineages are TNRC6B, MAPK8, and FAM149A. Each is linked with LIPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPT1-to-partner and partner-to-LIPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6B grouped by LIPT1-low versus LIPT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPT1→partner) and Y-score (partner→LIPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNRC6B →	+0.886	+3.064	<.001	.009	3	1
LARGE_INTESTINE	MAPK8 →	+0.846	+3.215	<.001	.009	3	1
LARGE_INTESTINE	FAM149A →	+1.603	+3.067	<.001	.009	3	1
LARGE_INTESTINE	RSPH4A →	+0.248	+3.259	<.001	.006	3	1
LARGE_INTESTINE	SNX3 →	+0.628	+3.082	<.001	.007	3	1
LARGE_INTESTINE	SRMS →	+0.916	+3.125	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

TNRC6B by LIPT1 expression — LARGE_INTESTINE

Explore this box plot interactively →