Across TCGA patient cohorts, LIPN mutation is significantly associated with the RNA expression of many other genes, with 1,587 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPN-associated genes across cancer lineages are USP9YP10, RNU6-271P, and RNU6ATAC14P. Each is linked with LIPN in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPN-to-partner and partner-to-LIPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPN→partner) and Y-score (partner→LIPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
UCEC	RNU6-271P →	+0.232	+2.977	<.001	.009	3	2
SKCM	RNU6ATAC14P →	+0.579	+2.730	<.001	.009	3	2
UCEC	MRPL37 →	+0.578	+3.700	.002	.001	3	2
BRCA	MIR3648-1 →	+0.068	+7.057	<.001	.009	3	1
BRCA	RNA5SP147 →	+0.222	+4.739	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,587 associations by consensus.

Exploration

LIPN survival (RNA) · tumor vs normal (RNA) · all LIPN data types