LIPM

Across TCGA patient cohorts, LIPM mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPM-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and Ku80. Each is linked with LIPM in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPM-to-partner and partner-to-LIPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LIPM-low versus LIPM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPM→partner) and Y-score (partner→LIPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.097	-2.401	.016	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.161	-2.584	.017	.010	3	1
UCEC	Ku80 →	+0.251	+2.183	.008	.033	3	1
UCEC	MEK1 →	+0.326	+2.584	.026	.010	3	1
UCEC	PDCD4 →	-0.381	-1.906	.044	.016	3	1
UCEC	Tuberin →	+0.251	+1.884	.020	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by LIPM expression — UCEC

Explore this box plot interactively →