Across TCGA patient cohorts, LIPJ mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPJ-associated genes across cancer lineages are EGFR_pY1173, A-Raf_pS299, and GATA6. Each is linked with LIPJ in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPJ-to-partner and partner-to-LIPJ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPJ→partner) and Y-score (partner→LIPJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.069	+1.727	.040	.026	3	1
UCEC	A-Raf_pS299 →	-0.107	-3.000	.034	.036	3	1
UCEC	GATA6 →	-0.164	-2.584	.015	.010	3	1
UCEC	Heregulin →	-0.118	-3.584	.023	.002	3	1
UCEC	INPP4B →	-0.330	-2.000	.016	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-2.321	.020	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

LIPJ survival (RNA) · tumor vs normal (RNA) · all LIPJ data types