Across TCGA cell cohorts, LIPI mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LIPI-associated genes across cancer lineages are KRTAP5-4, IFNA8, and H3-4. Each is linked with LIPI in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPI-to-partner and partner-to-LIPI results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPI→partner) and Y-score (partner→LIPI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP5-4 →	+0.031	+4.507	<.001	.001	3	2
SKIN	IFNA8 →	+0.018	+3.240	<.001	.004	3	1
SKIN	H3-4 →	+0.139	+2.722	.006	.009	3	1
SKIN	KCNH6 →	+0.020	+3.196	.001	.003	3	1
SKIN	IFNA13 →	+0.053	+2.688	.001	.008	3	1
SKIN	PPIAL4D →	+0.096	+3.069	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

LIPI survival (RNA) · tumor vs normal (RNA) · all LIPI data types