LIPF

Across TCGA cell cohorts, LIPF mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LIPF-associated genes across cancer lineages are TAS2R41, OR5C1, and OR1L1. Each is linked with LIPF in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPF-to-partner and partner-to-LIPF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R41 grouped by LIPF-low versus LIPF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPF→partner) and Y-score (partner→LIPF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R41 →	+0.035	+3.345	<.001	.007	3	1
SKIN	OR5C1 →	+0.105	+4.977	<.001	.007	3	1
SKIN	OR1L1 →	+0.023	+6.022	<.001	.001	3	1
SKIN	OR4E2 →	+0.015	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TAS2R41 by LIPF expression — LARGE_INTESTINE

Explore this box plot interactively →