LIPE

Across TCGA patient cohorts, LIPE protein abundance is significantly associated with the RNA expression of many other genes, with 11,052 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LIPE-associated genes across cancer lineages are SEMA3G, SCN4A, and KLF2. Each is linked with LIPE in more than 5 cancer types. Because this analysis shows association rather than direction, both LIPE-to-partner and partner-to-LIPE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIPE versus SEMA3G in CCRCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPE→partner) and Y-score (partner→LIPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEMA3G →	+1.035	+0.421	<.001	<.001	3	6
HNSC	SCN4A →	+1.081	+0.462	<.001	<.001	3	6
BRCA	KLF2 →	+1.062	+0.893	<.001	<.001	3	5
GBM	ASPA →	+1.191	+0.614	<.001	<.001	3	5
BRCA	PPP1R1A →	+1.412	+1.048	<.001	<.001	3	5
BRCA	SNED1 →	+0.969	+0.932	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,052 associations by consensus.

LIPE vs SEMA3G — CCRCC

Explore this scatter interactively →