LIPE

Across TCGA patient cohorts, LIPE mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPE-associated genes across cancer lineages are MIG-6, EGFR_pY1068, and Caspase-7-cleavedD198. Each is linked with LIPE in more than 2 cancer types. Because this analysis shows association rather than direction, both LIPE-to-partner and partner-to-LIPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by LIPE-low versus LIPE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPE→partner) and Y-score (partner→LIPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIG-6 →	+0.156	+2.195	.023	.032	3	3
UCEC	EGFR_pY1068 →	-0.195	-1.222	.016	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.676	+1.785	<.001	.007	3	3
UCEC	eIF4E →	+0.205	+2.000	.002	<.001	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.370	+1.916	.024	.009	3	2
UCEC	MEK1 →	+0.488	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MIG-6 by LIPE expression — SKCM

Explore this box plot interactively →