LIPA

Across TCGA patient cohorts, LIPA mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIPA-associated genes across cancer lineages are AGGF1P7, RNU7-11P, and RPL9P13. Each is linked with LIPA in more than 1 cancer types. Because this analysis shows association rather than direction, both LIPA-to-partner and partner-to-LIPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGGF1P7 grouped by LIPA-low versus LIPA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIPA→partner) and Y-score (partner→LIPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AGGF1P7 →	+0.062	+5.362	<.001	.005	3	2
COAD	RNU7-11P →	+0.990	+5.145	<.001	.007	3	2
BLCA	RPL9P13 →	+0.151	+5.106	<.001	.008	3	2
BLCA	RN7SL51P →	+0.283	+5.329	<.001	.006	3	2
UCEC	ADM →	+0.875	+2.425	.009	.002	3	1
UCEC	LAMTOR1 →	+0.364	+2.425	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

AGGF1P7 by LIPA expression — SKCM

Explore this box plot interactively →