LINGO4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LINGO4 mutation is significantly associated with the RNA expression of many other genes, with 1,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO4-associated genes across cancer lineages are RNU6-661P, RN7SL810P, and RNU6-1220P. Each is linked with LINGO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO4-to-partner and partner-to-LINGO4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO4→partner) and Y-score (partner→LINGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMRNU6-661P →+0.311+4.584<.001.00732
CESCRN7SL810P →+0.190+3.874<.001.00632
CESCRNU6-1220P →+0.195+5.252<.001.00232
CESCTSPAN9-IT1 →+0.109+3.653<.001.00932
BLCAMRPL51P2 →+0.114+7.640<.001.00932
LUSCMIR6816 →+0.594+5.038<.001.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,198 associations by consensus.

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