LINGO2

Across TCGA patient cohorts, LINGO2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,930 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LINGO2-associated proteins across cancer lineages are CACNA2D1, CDH13, and PRKD1. Each is linked with LINGO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LINGO2 versus CACNA2D1 in GBM, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CACNA2D1 →	+0.763	+0.835	<.001	<.001	3	4
GBM	CDH13 →	+0.738	+0.834	<.001	<.001	3	4
COAD	PRKD1 →	+0.855	+0.209	<.001	<.001	3	3
UCEC	PRKD1_S219 →	+0.872	+0.712	<.001	<.001	3	3
UCEC	PTBP2 →	+0.801	+0.888	<.001	<.001	3	3
UCEC	RAB11FIP5 →	+0.356	+1.049	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,930 associations by consensus.

LINGO2 vs CACNA2D1 — GBM

Explore this scatter interactively →