LINGO2

Across TCGA patient cohorts, LINGO2 protein abundance is significantly associated with the protein abundance of many other proteins, with 7,730 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LINGO2-associated proteins across cancer lineages are RCOR1_S260, RCOR3, and RECQL. Each is linked with LINGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LINGO2 versus RCOR1_S260 in GBM, with a Pearson correlation of -0.45.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCOR1_S260 →	-0.376	-0.375	<.001	<.001	3	1
GBM	RCOR3 →	-0.479	-0.472	<.001	<.001	3	1
GBM	RECQL →	-0.264	-0.286	<.001	<.001	3	1
GBM	RECQL_S597 →	-0.929	-0.456	<.001	<.001	3	1
GBM	RECQL5 →	-0.355	-0.460	<.001	<.001	3	1
GBM	RELA_S203 →	-0.765	-0.431	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,730 associations by consensus.

LINGO2 vs RCOR1_S260 — GBM

Explore this scatter interactively →