LINGO2

Across TCGA patient cohorts, LINGO2 mutation is significantly associated with the RNA expression of many other genes, with 4,217 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO2-associated genes across cancer lineages are TEDC2, FLT3LG, and CCM2L. Each is linked with LINGO2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEDC2 grouped by LINGO2-low versus LINGO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TEDC2 →	+0.614	+2.065	<.001	<.001	3	4
LUAD	FLT3LG →	-0.393	-3.567	.004	.002	3	4
UCEC	CCM2L →	-0.406	-1.621	<.001	<.001	3	4
UCEC	CPQ →	-0.427	-1.930	.001	.001	3	4
UCEC	HROB →	+0.550	+2.065	<.001	<.001	3	4
UCEC	PDSS1 →	+0.342	+3.119	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,217 associations by consensus.

TEDC2 by LINGO2 expression — UCEC

Explore this box plot interactively →