LINGO2

Across TCGA patient cohorts, LINGO2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO2-associated genes across cancer lineages are Cyclin-B1, Notch1, and 4E-BP1. Each is linked with LINGO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LINGO2-low versus LINGO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.805	+1.947	<.001	<.001	3	3
UCEC	Notch1 →	+0.156	+1.857	<.001	.004	3	3
UCEC	4E-BP1 →	+0.360	+4.169	<.001	<.001	3	3
STAD	Caveolin-1 →	-0.937	-3.321	.008	.010	3	2
COAD	14-3-3_epsilon →	+0.186	+2.832	.003	.034	3	2
COAD	PKC-b-II_pS660 →	-0.474	-3.000	.006	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-B1 by LINGO2 expression — UCEC

Explore this box plot interactively →