LINGO2

Across TCGA cell cohorts, LINGO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,273 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LINGO2-associated GO terms across cancer lineages are Response to ischemia, Cellular response to salt, and Regulation of stem cell population maintenance. Each is linked with LINGO2 in more than 4 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to ischemia grouped by LINGO2-low versus LINGO2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Response to ischemia →	-0.119	-1.444	<.001	<.001	3	5
BONE	Cellular response to salt →	+0.188	+1.553	<.001	<.001	3	5
LUNG_SCLC	Regulation of stem cell population maintenance →	+0.073	+1.360	.003	.002	3	5
LUNG_SCLC	Negative regulation of Golgi to plasma membrane protein transport →	-0.142	-1.274	<.001	.001	3	5
LUNG_SCLC	Lymphocyte chemotaxis →	-0.156	-1.508	<.001	.002	3	5
BREAST	Regulation of protein localization to mitochondrion →	+0.095	+0.505	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,273 associations by consensus.

Response to ischemia by LINGO2 expression — BONE

Explore this box plot interactively →