LINGO2

Across TCGA cell cohorts, LINGO2 mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LINGO2-associated genes across cancer lineages are AVP, TCP11X1, and GAGE12J. Each is linked with LINGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO2-to-partner and partner-to-LINGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by LINGO2-low versus LINGO2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO2→partner) and Y-score (partner→LINGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AVP →	+0.660	+2.584	.001	.004	3	2
BLOOD_Lymphoma	TCP11X1 →	+0.003	+4.247	<.001	.004	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
LUNG_SCLC	SSTR4 →	+0.064	+2.578	<.001	.004	3	1
LUNG_SCLC	DNASE2B →	+0.142	+3.222	.004	.007	3	1
LUNG_SCLC	GLYAT →	+0.110	+3.964	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

AVP by LINGO2 expression — LUNG_SCLC

Explore this box plot interactively →