LINGO1

Across TCGA patient cohorts, LINGO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,326 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LINGO1-associated proteins across cancer lineages are LRRFIP1, MYO1F_S1023, and EPM2AIP1. Each is linked with LINGO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LINGO1 versus LRRFIP1 in GBM, with a Pearson correlation of -0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRFIP1 →	-0.340	-1.270	<.001	<.001	3	5
GBM	MYO1F_S1023 →	-0.719	-1.219	<.001	<.001	3	5
UCEC	EPM2AIP1 →	+0.359	+0.812	.002	<.001	3	5
HNSC	PSME1 →	-0.372	-0.442	<.001	.003	3	4
LSCC	UBTF →	+0.281	+0.767	.001	<.001	3	4
UCEC	PSMB10 →	-0.517	-1.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,326 associations by consensus.

LINGO1 vs LRRFIP1 — GBM

Explore this scatter interactively →