LINGO1

Across TCGA patient cohorts, LINGO1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,692 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LINGO1-associated genes across cancer lineages are POM121L9P, NRXN3, and RAB6B. Each is linked with LINGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LINGO1 versus POM121L9P in GBM, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POM121L9P →	-0.824	-0.594	.002	<.001	3	2
GBM	NRXN3 →	+0.888	+0.336	<.001	.001	3	2
GBM	RAB6B →	+0.850	+0.438	<.001	<.001	3	2
UCEC	TNFRSF13C →	+0.746	+0.554	.001	.006	3	2
UCEC	RIMKLA →	+1.520	+0.695	.001	.002	3	2
GBM	ILF2P2 →	+0.714	+0.458	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,692 associations by consensus.

LINGO1 vs POM121L9P — GBM

Explore this scatter interactively →