LINGO1

Across TCGA patient cohorts, LINGO1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LINGO1-associated genes across cancer lineages are JNK2, ATM, and GAPDH. Each is linked with LINGO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LINGO1-low versus LINGO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.225	+2.249	<.001	.005	3	3
UCEC	ATM →	-0.498	-1.777	<.001	.002	3	3
LUSC	GAPDH →	+0.886	+3.179	.007	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.551	+1.999	.003	.008	3	2
UCEC	Annexin-1 →	+0.601	+3.999	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.275	-1.352	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK2 by LINGO1 expression — UCEC

Explore this box plot interactively →