LINGO1

Across TCGA cell cohorts, LINGO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,614 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LINGO1-associated GO terms across cancer lineages are Nucleoside triphosphate biosynthetic process, Regulation of DNA repair, and Renal vesicle formation. Each is linked with LINGO1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside triphosphate biosynthetic process grouped by LINGO1-low versus LINGO1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Nucleoside triphosphate biosynthetic process →	+0.082	+1.643	<.001	<.001	3	11
STOMACH	Regulation of DNA repair →	+0.061	+2.594	.001	<.001	3	11
STOMACH	Renal vesicle formation →	+1.530	+1.787	<.001	<.001	3	11
STOMACH	Metanephric renal vesicle formation →	+1.530	+1.787	<.001	<.001	3	11
OVARY	Dendritic cell differentiation →	-0.172	-1.363	<.001	<.001	3	10
LUNG_SCLC	Nucleoside triphosphate metabolic process →	+0.079	+1.949	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,614 associations by consensus.

Nucleoside triphosphate biosynthetic process by LINGO1 expression — OVARY

Explore this box plot interactively →