LINGO1

Across TCGA cell cohorts, LINGO1 mutation is significantly associated with the drug of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LINGO1-associated genes across cancer lineages are Ara-G, T0901317, and AICA Ribonucleotide. Each is linked with LINGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LINGO1-to-partner and partner-to-LINGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ara-G grouped by LINGO1-low versus LINGO1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LINGO1→partner) and Y-score (partner→LINGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Ara-G →	+0.539	+2.038	.038	.046	3	2
LARGE_INTESTINE	T0901317 →	+0.295	+2.722	.032	.040	3	1
BLOOD_Leukemia	AICA Ribonucleotide →	-0.460	-2.750	<.001	.049	3	1
BLOOD_Leukemia	Selumetinib →	-0.678	-3.060	.017	.014	3	1
BLOOD_Leukemia	Entinostat →	-0.514	-3.000	.001	.023	3	1
BLOOD_Leukemia	PFI3 →	-0.197	-2.748	.014	.048	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Ara-G by LINGO1 expression — BLOOD_Leukemia

Explore this box plot interactively →