LINGO1-AS2

Across TCGA pan-cancer cohorts, LINGO1-AS2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated LINGO1-AS2 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher LINGO1-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LINGO1-AS2 expression acts as an unfavorable survival marker, although some lineages such as LGG and BRCA show a favorable association.

STAD, KIRC, and COAD are the cancer types where LINGO1-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.142	0.575	.001	51	view →
KIRC	DFS	Tertile	IV	0.307	0.633	.024	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
LGG	OS	Tertile	All	0.550	0.426	.004	22	view →
THCA	OS	Tertile	II,III,IV	0.255	0.909	.032	18	view →
UCEC	DFS	Tertile	IV	0.206	0.704	.033	18	view →
PRAD	OS	Tertile	All	0.826	0.990	<.001	18	view →
BRCA	DFS	Tertile	All	1.000	0.946	.029	12	view →
SARC	DFS	Tertile	All	0.922	0.558	.019	9	view →
ACC	DFS	Tertile	All	0.195	0.748	.003	9	view →
SKCM	DFS	Tertile	II,III,IV	0.736	0.551	.030	3	view →
LIHC	DFS	Tertile	All	1.000	0.273	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

LINGO1-AS2–STAD (OS)

Open the STAD breakdown →