LINGO1-AS1

Across TCGA pan-cancer cohorts, LINGO1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated LINGO1-AS1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher LINGO1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LINGO1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

DLBC, KIRP, and LUSC are the cancer types where LINGO1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	27	view →
KIRP	DFS	Tertile	All	0.741	0.886	.017	21	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
ACC	DFS	Quartile	III,IV	0.312	0.681	.004	18	view →
SKCM	DFS	Median	All	0.679	0.559	.015	13	view →
KIRC	DFS	Tertile	All	0.514	0.668	.005	13	view →
THYM	OS	Tertile	II,III,IV	0.817	1.000	.018	12	view →
ESCA	OS	Quartile	IV	0.095	0.495	.025	12	view →
CESC	DFS	Tertile	III,IV	0.395	0.658	.043	12	view →
LGG	OS	Quartile	All	0.957	0.769	.001	12	view →
LAML	DFS	Quartile	All	0.430	0.669	.030	8	view →
KICH	DFS	Median	All	1.000	0.716	.015	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

LINGO1-AS1–DLBC (DFS)

Open the DLBC breakdown →