LINGO1-AS1

Across TCGA pan-cancer cohorts, LINGO1-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LINGO1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where LINGO1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINGO1-AS1 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

BRCA, LIHC, and READ are the cancer types where LINGO1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINGO1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.045	.018	4	view →
LIHC	Female	II,III,IV	+0.038	.006	3	view →
READ	All	III,IV	−0.045	.012	2	view →
KICH	Female	II,III,IV	+0.038	.033	1	view →
THCA	All	All	+0.015	.043	1	view →
KIRC	All	All	+0.011	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LINGO1-AS1–BRCA

Open the BRCA breakdown →