Across TCGA pan-cancer cohorts, LINC02778 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LINC02778’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02778 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02778 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and KIRP are the cancer types where LINC02778 tumor–normal differential expression is most reproducible.