Across TCGA pan-cancer cohorts, LINC02659 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of LINC02659’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where LINC02659 RNA is repressed in tumor relative to normal tissue. In most cancer types LINC02659 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KICH are the cancer types where LINC02659 tumor–normal differential expression is most reproducible.