long intergenic non-protein coding RNA 2538Genealiases: []
Q-omics provides the consensus-scored LINC02538 profile across patient tissues and cancer cell-line models. LINC02538 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, LINC02538 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, LINC02538 RNA expression shows 12,214 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRC, HNSC, and TGCT as cancer lineages where LINC02538 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC02538 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC02538 survival associations across molecular data types. LINC02538 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC02538 RNA expression–survival associations across cancer types. High LINC02538 expression shows unfavorable associations in ACC and LAML, but favorable associations in KIRC, HNSC, PAAD and SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for LINC02538 RNA expression.
This table summarizes LINC02538 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC02538. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC02538 shows lower tumor expression in HNSC, KICH, THCA, UCEC and BLCA and higher tumor expression in KIRC. The HNSC box plot shows higher LINC02538 RNA expression in normal versus tumor tissue (log2 FC = −0.980, t-test p < 0.001).
This table shows molecular features associated with LINC02538 in patient tissues and cancer cell lines. In patient samples, LINC02538 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
