long intergenic non-protein coding RNA 2458Genealiases: []
Q-omics provides the consensus-scored LINC02458 profile across patient tissues and cancer cell-line models. LINC02458 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, LINC02458 is differentially expressed in 10, with the highest sampling consensus in LUSC. Additionally, LINC02458 RNA expression shows 14,307 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, LUSC, and TGCT as cancer lineages where LINC02458 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC02458 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC02458 survival associations across molecular data types. LINC02458 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC02458 RNA expression–survival associations across cancer types. High LINC02458 expression shows unfavorable associations in KIRP, KIRC, ACC, LIHC and READ, but favorable associations in MESO. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for LINC02458 RNA expression.
This table summarizes LINC02458 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC02458. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC02458 shows lower tumor expression in LUSC, KICH and BRCA and higher tumor expression in THCA, LIHC and HNSC. The LUSC box plot shows higher LINC02458 RNA expression in normal versus tumor tissue (log2 FC = −0.203, t-test p < 0.001).
This table shows molecular features associated with LINC02458 in patient tissues and cancer cell lines. In patient samples, LINC02458 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
