LINC02457

Across TCGA pan-cancer cohorts, LINC02457 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LINC02457’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02457 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02457 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

HNSC, LUSC, and BRCA are the cancer types where LINC02457 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02457 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.609	<.001	11	view →
LUSC	Male	All	+0.742	<.001	5	view →
BRCA	All	III,IV	−0.058	.044	2	view →
KIRP	All	All	+0.041	.017	2	view →
KIRC	All	All	+0.035	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

LINC02457–HNSC

Open the HNSC breakdown →