LINC02428

Across TCGA pan-cancer cohorts, LINC02428 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LINC02428’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LINC02428 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02428 is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where LINC02428 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02428 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.854	<.001	11	view →
LIHC	Male	II,III,IV	−3.099	<.001	8	view →
LUSC	Female	II,III,IV	+2.071	<.001	7	view →
COAD	All	All	+0.454	<.001	7	view →
STAD	All	All	+0.733	<.001	6	view →
CHOL	Female	All	−4.943	<.001	5	view →
LUAD	All	All	+0.346	<.001	5	view →
BRCA	Female	II,III,IV	−0.168	.009	4	view →
UCEC	All	All	+0.342	.041	2	view →
BLCA	All	III,IV	+0.952	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LINC02428–HNSC

Open the HNSC breakdown →