Q-omics provides the consensus-scored LINC02246 profile across patient tissues and cancer cell-line models. LINC02246 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LINC02246 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, LINC02246 RNA expression shows 18,601 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and HNSC as cancer lineages where LINC02246 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LINC02246 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LINC02246 survival associations across molecular data types. LINC02246 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LINC02246 RNA expression–survival associations across cancer types. High LINC02246 expression shows unfavorable associations in UVM, ACC, MESO, HNSC, KIRP and SARC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UVM as the clearest survival context for LINC02246 RNA expression.
This table summarizes LINC02246 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for LINC02246. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LINC02246 shows lower tumor expression in KICH and higher tumor expression in HNSC, LUAD, BLCA, BRCA and LUSC. The HNSC box plot shows higher LINC02246 RNA expression in tumor versus normal tissue (log2 FC = +0.187, t-test p < 0.001).
This table shows molecular features associated with LINC02246 in patient tissues and cancer cell lines. In patient samples, LINC02246 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
