LINC02227

Across TCGA patient cohorts, LINC02227 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,975 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LINC02227-associated GO terms across cancer lineages are Negative regulation of leukocyte apoptotic process, Positive regulation of CD4-positive, alpha-beta T cell activation, and Alpha-beta T cell activation. Each is linked with LINC02227 in more than 21 cancer types. Because this analysis shows association rather than direction, both LINC02227-to-partner and partner-to-LINC02227 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of leukocyte apoptotic process grouped by LINC02227-low versus LINC02227-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LINC02227→partner) and Y-score (partner→LINC02227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of leukocyte apoptotic process →	+0.070	+0.108	<.001	<.001	3	22
SKCM	Positive regulation of CD4-positive, alpha-beta T cell activation →	+0.051	+0.098	<.001	<.001	3	21
SKCM	Alpha-beta T cell activation →	+0.061	+0.099	<.001	<.001	3	21
SKCM	Positive regulation of alpha-beta T cell activation →	+0.062	+0.119	<.001	<.001	3	21
ESCA	Antigen receptor-mediated signaling pathway →	+0.080	+0.147	<.001	.002	3	21
SKCM	Positive regulation of T cell proliferation →	+0.069	+0.103	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,975 associations by consensus.

Negative regulation of leukocyte apoptotic process by LINC02227 expression — STAD

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