LINC02227

Across TCGA pan-cancer cohorts, LINC02227 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LINC02227’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LINC02227 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LINC02227 is over-expressed in tumor, although a few such as BRCA and READ show the opposite, repressed pattern.

KIRC, LUAD, and BRCA are the cancer types where LINC02227 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LINC02227 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.030	<.001	8	view →
LUAD	All	All	+0.073	<.001	7	view →
BRCA	All	III,IV	−0.187	<.001	6	view →
CHOL	Female	All	+0.060	<.001	3	view →
READ	Female	All	−0.092	.009	2	view →
KICH	Male	III,IV	−0.032	.040	2	view →
LIHC	All	III,IV	+0.015	.023	2	view →
LUSC	All	III,IV	−0.053	.009	1	view →
THCA	All	All	−0.028	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LINC02227–KIRC

Open the KIRC breakdown →