LINC02181

Across TCGA pan-cancer cohorts, LINC02181 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated LINC02181 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LINC02181 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LINC02181 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

HNSC, THYM, and LUAD are the cancer types where LINC02181 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.342	0.692	<.001	45	view →
THYM	OS	Quartile	All	0.814	1.000	.016	17	view →
LUAD	DFS	Median	II,III,IV	0.388	0.190	.019	16	view →
KIRC	DFS	Quartile	All	0.883	0.697	.006	14	view →
SKCM	OS	Tertile	II,III,IV	0.500	0.318	.004	14	view →
READ	OS	Tertile	All	1.000	0.539	.010	12	view →
LIHC	DFS	Tertile	All	0.294	0.479	.011	12	view →
UVM	OS	Tertile	III,IV	0.136	0.874	<.001	9	view →
LUSC	DFS	Median	II,III,IV	0.718	0.355	.004	7	view →
PCPG	DFS	Tertile	All	0.964	0.667	.018	7	view →
COAD	DFS	Tertile	II,III,IV	0.757	0.601	.027	6	view →
STAD	DFS	Tertile	All	0.212	0.447	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

LINC02181–HNSC (OS)

Open the HNSC breakdown →